8 cosas de tu sistema inmune que quizá no sabías

Hay cosas muy lindas de tu sistema inmune que tal vez no sabes... Hoy te platico de ocho cosas del sistema inmune: las barreras del cuerpo, el microbioma, la diferencia entre inmunidad innata y adaptativa, la memoria inmunológica y un poco de cómo se reorganiza el sistema inmune con la edad. También hablamos de mitos comunes (como el famoso “10 a 1” entre bacterias y células nuestras), de la inmunidad entrenada, y algo rápido del sistema inmune en el cerebro. ¡Un poquito de lo importante de tu sistema inmunológico! Aquí los links a los artículos: Sender R, Fuchs S, Milo R. Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans. Cell. 2016;164(3):337-340. doi:10.1016/j.cell.2016.01.013. https://www.cell.com/cell/fulltext/S0092-8674(16)00053-2 Sender R, Fuchs S, Milo R. Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol. 2016;14(8):e1002533. doi:10.1371/journal.pbio.1002533. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002533 Sender R, Weiss Y, Navon Y, et al. The total mass, number, and distribution of immune cells in the human body. Proc Natl Acad Sci U S A. 2023;120(44):e2308511120. doi:10.1073/pnas.2308511120. https://www.pnas.org/doi/10.1073/pnas.2308511120 Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol. 2014;14(10):667-685. doi:10.1038/nri3738. https://www.nature.com/articles/nri3738 Tonegawa S. Somatic generation of antibody diversity. Nature. 1983;302(5909):575-581. doi:10.1038/302575a0. https://www.nature.com/articles/302575a0 Offit PA, Quarles J, Gerber MA, et al. Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system? Pediatrics. 2002;109(1):124-129. doi:10.1542/peds.109.1.124. https://publications.aap.org/pediatrics/article/109/1/124/64748/ Netea MG, Joosten LAB, Latz E, et al. Trained immunity: A program of innate immune memory in health and disease. Science. 2016;352(6284):aaf1098. doi:10.1126/science.aaf1098. https://www.science.org/doi/10.1126/science.aaf1098 Netea MG, Dominguez-Andres J, Barreiro LB, et al. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020;20(6):375-388. doi:10.1038/s41577-020-0285-6. https://www.nature.com/articles/s41577-020-0285-6 Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 2011;331(6024):1565-1570. doi:10.1126/science.1203486. https://www.science.org/doi/10.1126/science.1203486 Palmer DB. The effect of age on thymic function. Front Immunol. 2013;4:316. doi:10.3389/fimmu.2013.00316. https://www.frontiersin.org/articles/10.3389/fimmu.2013.00316/full Besedovsky L, Lange T, Haack M. The Sleep-Immune Crosstalk in Health and Disease. Physiol Rev. 2019;99(3):1325-1380. doi:10.1152/physrev.00010.2018. https://journals.physiology.org/doi/full/10.1152/physrev.00010.2018 Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337-341. doi:10.1038/nature14432. https://www.nature.com/articles/nature14432 Ginhoux F, Greter M, Leboeuf M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330(6005):841-845. doi:10.1126/science.1194637. https://www.science.org/doi/10.1126/science.1194637 Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S4-S9. doi:10.1093/gerona/glu057. https://academic.oup.com/biomedgerontology/article/69/Suppl_1/S4/570011